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A July 22, Abstract Simultaneous inference is a common problem in many areas of application. If multiple null hypotheses are tested simultaneously, the probability of rejecting er- roneously at least one of them increases beyond the pre-specified significance level. Simultaneous inference procedures have to be used which adjust for multiplicity and thus control the overall type I error rate. In this paper we describe simultaneous infer- ence procedures in general parametric models, where the experimental questions are specified through a linear combination of elemental model parameters. The frame- work described here is quite general and extends the canonical theory of multiple comparison procedures in ANOVA models to linear regression problems, generalized linear models, linear mixed effects models, the Cox model, robust linear models, etc. KGaA, Weinheim; available online http:
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Main article: Behavioral addiction The term behavioral addiction refers to a compulsion to engage in a natural reward — which is a behavior that is inherently rewarding i. There is evidence from functional neuroimaging that gambling activates the reward system and the mesolimbic pathway in particular. Addiction vulnerability There are a number of genetic and environmental risk factors for developing an addiction, that vary across the population.
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The pathogenicity of the murine astrovirus was not known. Legislation in research[ edit ] United Kingdom[ edit ] In the UK, as with all other vertebrates and some invertebrates, any scientific procedure which is likely to cause "pain, suffering, distress or lasting harm" is regulated by the Home Office under the Animals Scientific Procedures Act UK regulations are considered amongst the most comprehensive and rigorous in the world. Compliance with the PHS is required for a research project to receive federal funding. Many academic research institutes seek accreditation voluntarily, often through the Association for Assessment and Accreditation of Laboratory Animal Care , which maintains the standards of care found within The Guide for the Care and Use of Laboratory Animals and the PHS policy.
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